Seo Hyung Suk, Lee Dong Hoon, Park Sung Hye, Min Hye Sook, Na Dong Gyu
Department of Radiology, Korea University Ansan Hospital, Ansan-si, Kyunggi-do, 425-707, Korea.
J Clin Ultrasound. 2009 Nov-Dec;37(9):493-500. doi: 10.1002/jcu.20625.
The purpose of this study was to determine whether sonography (US) can usefully differentiate thyroid follicular adenoma (FA) and follicular carcinoma (FC).
This retrospective study included 60 pathologically proven FAs and 66 FCs in 123 consecutive patients (17 males and 106 females) with a mean age of 47 +/- 13 years, (17-73 years) who underwent thyroid surgery. We analyzed US features of each nodule, including maximum diameter, echogenicity, composition, presence of calcification, margins, and presence of halo. The frequencies of each US feature were compared by using the chi(2) test or Fisher's exact test between FAs and FCs. The relative risk of malignancy was evaluated by logistic regression analysis.
Isohypoechoic echogenicity, predominantly solid or mixed echotexture, and presence of microcalcifications or rim calcifications were associated with FC (p < 0.05). Logistic regression analysis demonstrated that predominantly solid or mixed echotexture and microcalcifications or rim calcifications were associated with significant increases in relative risk for FC (odds ratio 8.1 and odds ratio 13.5, respectively, p < 0.01).
The US features of isohypoechoic echogenicity, predominantly solid or mixed echotexture, and microcalcifications or rim calcifications are more common in FC than in FA.
本研究旨在确定超声检查（US）能否有效鉴别甲状腺滤泡性腺瘤（FA）和滤泡癌（FC）。
本回顾性研究纳入了123例连续接受甲状腺手术的患者（17例男性和106例女性），平均年龄47±13岁（17 - 73岁），其中有60例经病理证实为FA，66例为FC。我们分析了每个结节的超声特征，包括最大直径、回声、成分、钙化情况、边界以及晕圈情况。通过卡方检验或Fisher精确检验比较FA和FC之间各超声特征的频率。采用逻辑回归分析评估恶性肿瘤的相对风险。
等回声或低回声、主要为实性或混合性回声质地以及存在微钙化或边缘钙化与FC相关（p < 0.05）。逻辑回归分析表明，主要为实性或混合性回声质地以及微钙化或边缘钙化与FC的相对风险显著增加相关（优势比分别为8.1和13.5，p < 0.01）。
等回声或低回声、主要为实性或混合性回声质地以及微钙化或边缘钙化的超声特征在FC中比在FA中更常见。
