Deng M Z, Chen G Q, Phillips M R
Guangzhou City Psychiatric Hospital, Guangdong, People's Republic of China.
Am J Psychiatry. 1990 Sep;147(9):1149-55. doi: 10.1176/ajp.147.9.1149.
In a prospective study of an estimated 9,792 inpatients treated with neuroleptic medication at a large Chinese psychiatric hospital, 12 patients developed neuroleptic malignant syndrome. The estimated prevalence of neuroleptic malignant syndrome in these psychiatric inpatients was 1.23/1,000 (95% confidence interval = 0.63/1,000 to 2.14/1,000). Unlike other investigators, the authors found that young adulthood, nonschizophrenic illness, oral high-potency neuroleptics, and concurrent use of lithium were not important risk factors for neuroleptic malignant syndrome. However, depot fluphenazine decanoate, particularly if used without an antiparkinsonian agent, was a risk factor.
在一家大型中国精神病医院对约9792名接受抗精神病药物治疗的住院患者进行的前瞻性研究中，有12名患者出现了抗精神病药恶性综合征。这些精神科住院患者中抗精神病药恶性综合征的估计患病率为1.23/1000（95%置信区间=0.63/1000至2.14/1000）。与其他研究者不同，作者发现青年期、非精神分裂症疾病、口服高效抗精神病药以及同时使用锂并非抗精神病药恶性综合征的重要危险因素。然而，长效氟奋乃静癸酸酯，特别是在未使用抗帕金森病药物的情况下使用，是一个危险因素。
