Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon.
Phytochemistry. 2009 Jul-Aug;70(11-12):1442-7. doi: 10.1016/j.phytochem.2009.08.007. Epub 2009 Sep 9.
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC(50)=2.0-6.5 microM, but no cytotoxic effect was observed (IC(50)>100 microM).
从 F. heitzii（Letouzey）中分离得到两种酰胺，即 heitziamide A 和 heitziamide B，以及两种苯乙醇类化合物，即 heitziethanoid A 和 heitziethanoid B，此外还分离得到了 13 种已知化合物。通过光谱分析确定了所有化合物的结构。在化学发光测定法中，对 9 种化合物的氧化爆发抑制活性和对 PC-3 前列腺癌细胞的细胞毒性进行了评估。所有化合物在与血清调理的酵母聚糖激活时，均在 IC 50 = 2.0-6.5 μM 的范围内对吞噬反应表现出明显的抑制作用，但没有观察到细胞毒性作用（IC 50 > 100 μM）。
