Hamidifard Sharareh, Fakhari Ali, Mahboob Soltanali, Gargari Bahram Pourghassem
Department of Biochemistry, Nutrition and Diet Therapy, Nutritional Research Center, Tabriz University of Medical Sciences, Iran.
Psychiatry Res. 2009 Oct 30;169(3):253-6. doi: 10.1016/j.psychres.2008.06.033. Epub 2009 Sep 10.
Depression and cardiovascular disease are among the most prevalent health problems. The evidence that depression is a risk factor for the development and progression of coronary heart disease has strengthened over the past several years, but the exact reasons are not yet clear. Elevated lipoprotein (a) (Lp(a)) concentrations seem to be the major factor for the progression of the atherosclerosis and coronary heart disease. In this study, we measured the plasma levels of Lp(a) in 35 patients with major depressive disorder and 35 healthy controls. The two groups were matched by age and gender. Lp(a) measurement was performed using an immunoturbidimetric method. Total cholesterol was significantly lower in the patient group (mean +/-SD: 144.65+/-22.13 vs. 186.14+/-34.48 mg/dl. The Lp(a) levels of the patient group differed significantly from control values. Patients with major depressive disorder had higher plasma levels of Lp(a) than healthy controls (34.94+/-18.01 vs. 20.08+/-11.27 mg/dl). The results of the present study suggest that the increase of Lp(a) may contribute to higher cardiovascular risk in patients with major depressive disorder.
抑郁症和心血管疾病是最常见的健康问题。在过去几年里，抑郁症是冠心病发生和发展的危险因素这一证据得到了加强，但确切原因尚不清楚。脂蛋白（a）[Lp（a）]浓度升高似乎是动脉粥样硬化和冠心病进展的主要因素。在本研究中，我们测量了35例重度抑郁症患者和35例健康对照者的血浆Lp（a）水平。两组在年龄和性别上相匹配。采用免疫比浊法进行Lp（a）测定。患者组的总胆固醇显著较低（均值±标准差：144.65±22.13 vs. 186.14±34.48mg/dl）。患者组的Lp（a）水平与对照值有显著差异。重度抑郁症患者的血浆Lp（a）水平高于健康对照者（34.94±18.01 vs. 20.08±11.27mg/dl）。本研究结果表明，Lp（a）升高可能导致重度抑郁症患者心血管风险增加。
