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解析反义技术在抗生素药物研发中的应用

Making sense of antisense in antibiotic drug discovery.

作者信息

Wright Gerard D

机构信息

M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, ON, Canada.

出版信息

Cell Host Microbe. 2009 Sep 17;6(3):197-8. doi: 10.1016/j.chom.2009.08.009.

DOI:10.1016/j.chom.2009.08.009
PMID:19748460
Abstract

In an era of increasing antibiotic resistance, growing clinical need for new drugs, and few lead molecules, new research is helping to identify new targets and the mechanism of action of lead molecules.

摘要

在抗生素耐药性不断增加、对新药的临床需求不断增长且先导分子稀少的时代,新的研究有助于确定新的靶点以及先导分子的作用机制。

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