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Bioorg Med Chem Lett. 2009 Oct 15;19(20):5861-3. doi: 10.1016/j.bmcl.2009.08.083. Epub 2009 Aug 27.
In this Letter, a novel strategy for assessment of ligand promiscuity is described. By using a carefully selected small set of kinases together with multivariate statistical methods, a measure of selectivity can be estimated. This will facilitate an appropriate selection of compounds for further development in lead generation and optimization.
在这封信件中，描述了一种评估配体混杂性的新策略。通过使用精心挑选的一小部分激酶和多元统计方法，可以估计出一种选择性度量标准。这将有助于为先导化合物的生成和优化进一步选择合适的化合物。
