USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933-0166, USA.
J Anim Sci. 2010 Jan;88(1):1-15. doi: 10.2527/jas.2009-1985. Epub 2009 Sep 11.
The ability to identify young females with superior reproduction would have a large economic impact on commercial swine production. Previous studies have discovered SNP associated with economically important traits such as litter size, growth rate, and feed intake. The objective of this study was to test for association of candidate SNP with sow prolificacy reproductive traits in gilts of a Landrace-Duroc-Yorkshire composite population. Association analyses regressed additive (A), dominant (D), and imprinting (I) SNP effects on each trait with an animal model. A carnitine palmitoyltransferase 1A SNP and a glycogen synthase 1 SNP were associated with age at puberty (AP; D = 10 d; P = 0. 0037 and A = 3.8 d; P = 0.0078, respectively). Four IGF2 SNP were associated with AP as well, having additive or dominant effects (3.2 to 5.8 d; P < or = 0.0052). Two mannosidase 2B2 SNP and 2 prolactin receptor (PRLR) SNP were also associated with AP. Solute carrier 22, subfamily member 5 SNP was weakly associated with AP (D = 3.9 d; P < 0.10). Polymorphisms within glycogen synthase 1 and protein kinase AMP-activated, gamma 3 noncatalytic subunit had associations with ovulation rate. Estrogen receptor (ESR) 1, ESR2, PPAR gamma coactivator 1, and IGFBP3 SNP were significantly associated with weaning-to-estrus interval. Two PRLR SNP were associated with total number of piglets born (A = 0.57 piglets; P = 0.0095 and D = 0.61 piglets; P = 0.0016, respectively). A SNP within PRLR was also associated with number of piglets born alive (D = 0.61; P = 0.0016). The PPAR gamma coactivator 1 SNP was associated with total number of piglets born (D = 0.38 piglets; P = 0.0391) and number of piglets born alive (D = 0.53 piglets; P = 0.0032). The SNP within ESR1 (A = 0.65 piglets; P = 0.0950), ESR2 (A = -0.33 piglets; P = 0.0176), IGF2 SNP (A = -0.26 piglets; P = 0.0032), and IGFBP3 SNP (D = 0.35 piglets; P = 0.0683) were associated with number of piglets born dead. A leptin SNP was associated with mummified fetuses (D = 0.09 piglets; P = 0.0978). Many of the SNP analyzed in this study are from genes involved in regulation of metabolism, suggesting that there is an important link between physiological events associated with reproduction and energy utilization. Furthermore, these production and growth trait SNP may serve to assist in selection of young females for superior reproductive performance.
鉴定具有优秀繁殖能力的年轻雌性的能力将对商业养猪生产产生重大的经济影响。先前的研究已经发现了与产仔数、生长速度和饲料摄入量等经济重要性状相关的 SNP。本研究的目的是检验候选 SNP 与长白猪-杜洛克-大约克夏三元杂交猪母猪繁殖性状的相关性。关联分析采用动物模型回归 SNP 的加性（A）、显性（D）和印迹（I）效应。肉碱棕榈酰转移酶 1A SNP 和糖原合成酶 1 SNP 与初情期（AP；D = 10 d；P = 0.0037 和 A = 3.8 d；P = 0.0078）有关。4 个 IGF2 SNP 也与 AP 有关，具有加性或显性效应（3.2 至 5.8 d；P≤0.0052）。两个甘露糖苷酶 2B2 SNP 和 2 个催乳素受体（PRLR）SNP 也与 AP 有关。溶质载体 22，亚家族成员 5 SNP 与 AP 呈弱相关（D = 3.9 d；P<0.10）。糖原合成酶 1 和蛋白激酶 AMP 激活，γ 3 非催化亚基内的多态性与排卵率有关。雌激素受体（ESR）1、ESR2、过氧化物酶体增殖物激活受体γ共激活因子 1 和 IGFBP3 SNP 与断奶至发情间隔显著相关。2 个 PRLR SNP 与总产仔数有关（A = 0.57 头；P = 0.0095 和 D = 0.61 头；P = 0.0016）。PRLR 内的 SNP 也与活产仔数有关（D = 0.61；P = 0.0016）。过氧化物酶体增殖物激活受体 γ共激活因子 1 SNP 与总产仔数（D = 0.38 头；P = 0.0391）和活产仔数（D = 0.53 头；P = 0.0032）有关。ESR1 内的 SNP（A = 0.65 头；P = 0.0950）、ESR2（A = -0.33 头；P = 0.0176）、IGF2 SNP（A = -0.26 头；P = 0.0032）和 IGFBP3 SNP（D = 0.35 头；P = 0.0683）与死产仔数有关。瘦素 SNP 与木乃伊胎儿有关（D = 0.09 头；P = 0.0978）。本研究分析的许多 SNP 来自参与代谢调节的基因，这表明与繁殖相关的生理事件与能量利用之间存在重要联系。此外，这些生产和生长性状 SNP 可能有助于选择具有优秀繁殖性能的年轻雌性。
