Shrikhande S V, Barreto G, Koliopanos A
Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Mumbai, India.
Indian J Cancer. 2009 Oct-Dec;46(4):288-96. doi: 10.4103/0019-509X.55548.
Pancreatic cancer is a devastating disease with a dismal prognosis and early detection remains a challenge. On the background that inflammation is one of the key steps in the development of cancer, it is natural that chronic pancreatitis is considered as one of the etiological factors for the development of pancreatic cancer. However, the process of pancreatic carcinogenesis is a multifactorial phenomenon rather than a process that evolves solely via inflammation. This review attempts to put into perspective the association between different etiological forms of chronic pancreatitis and pancreatic cancer, and the diverse mechanisms operational in the process of pancreatic carcinogenesis. Furthermore, the clinical relevance of the current understanding of the relationship between chronic pancreatitis and pancreatic cancer, especially with regard to the pancreatic head mass of uncertain etiology, is discussed in this review.
胰腺癌是一种预后极差的毁灭性疾病，早期检测仍然是一项挑战。鉴于炎症是癌症发展的关键步骤之一，慢性胰腺炎自然被视为胰腺癌发生的病因之一。然而，胰腺癌的发生过程是一个多因素现象，而非仅通过炎症演变的过程。本综述试图阐述不同病因形式的慢性胰腺炎与胰腺癌之间的关联，以及胰腺癌发生过程中多种起作用的机制。此外，本综述还讨论了目前对慢性胰腺炎与胰腺癌关系的理解的临床相关性，特别是对于病因不明的胰头部肿块而言。
