Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health Japan, Yahatanishiku, Kitakyusyu, Japan. yamaguch @ med.uoeh-u.ac.jp
Pancreatology. 2011;11 Suppl 2:3-6. doi: 10.1159/000323477. Epub 2011 Apr 5.
The clinical outcome of patients with pancreatic cancer remains dismal despite recent advances in diagnostic and therapeutic modalities. Several risk factors have been reported regarding the development of pancreatic cancer. These risk factors include family history, accompanying diseases, and lifestyle/personal habits. Family history includes that of pancreatic cancer and hereditary pancreatic cancer syndrome. Accompanying diseases that increase the risk include diabetes mellitus, obesity, chronic pancreatitis, hereditary pancreatic cancer syndrome and intraductal papillary mucinous neoplasms. Lifestyle-associated factors include smoking and diet. Detailed examination of patients with such risk factors is warranted, but the cost-benefit effect should be considered. Thus, patients with more than one risk factor should be carefully followed up, and periodic examination of such patients is necessary to ensure the detection of smaller and less-advanced pancreatic cancer lesions and thus to improve the clinical outcome of patients with pancreatic cancer.
尽管在诊断和治疗方式上取得了一些进展，但胰腺癌患者的临床预后仍然不容乐观。据报道，胰腺癌的发生与一些风险因素有关，这些因素包括家族史、伴随疾病和生活方式/个人习惯。家族史包括胰腺癌和遗传性胰腺癌综合征的家族史。增加风险的伴随疾病包括糖尿病、肥胖、慢性胰腺炎、遗传性胰腺癌综合征和胰管内乳头状黏液性肿瘤。与生活方式相关的因素包括吸烟和饮食。对于有这些风险因素的患者，需要进行详细检查，但需要考虑成本效益。因此，对于有一个以上风险因素的患者应进行仔细随访，对这些患者进行定期检查对于发现较小和较早期的胰腺癌病变是必要的，从而改善胰腺癌患者的临床预后。
