Department of Cardiology, Aalborg Hospital, Aarhus University Hospital, Sdr Skovvej 15, 9000 Aalborg, Denmark.
Eur Heart J. 2010 Jan;31(1):29-34. doi: 10.1093/eurheartj/ehp375. Epub 2009 Sep 14.
To study the effect of fish consumption on the risk of acute coronary syndrome (ACS) in healthy subjects.
This Danish follow-up study included 57,053 men and women between 50 and 64 years. Intake of lean and fatty fish was estimated from a detailed and validated food frequency questionnaire. Potential cases of ACS were identified through nationwide medical databases. A total of 1122 cases of ACS were verified during a mean follow-up period of 7.6 years. Among men, intake of fatty fish was associated with a lower risk of ACS. For men in the highest quintile of fish intake compared with the lowest quintile, the hazard ratio was 0.67 (95% confidence interval: 0.53-0.85). The inverse association was observed for intakes >6 g of fatty fish per day with no obvious additional benefit observed for higher intakes. Intake of lean fish was not associated with ACS. There were few cases of ACS and results were not consistent in women.
In conclusion, a modest intake of fatty fish was associated with a lower risk of ACS in middle-aged men, whereas no consistent associations were observed among women.
研究健康人群中食用鱼类对急性冠脉综合征（ACS）风险的影响。
这是一项丹麦随访研究，共纳入 57053 名 50 至 64 岁的男性和女性。通过详细和验证的食物频率问卷评估瘦鱼和肥鱼的摄入量。通过全国性的医疗数据库确定 ACS 的潜在病例。在平均 7.6 年的随访期间，共确诊了 1122 例 ACS。在男性中，食用肥鱼与 ACS 风险降低相关。与最低五分位组相比，摄入最高五分位组的男性发生 ACS 的风险比为 0.67（95%置信区间：0.53-0.85）。对于每天摄入>6 克肥鱼的人群，也观察到了这种反向关联，而更高的摄入量并未观察到明显的额外益处。摄入瘦鱼与 ACS 无关。ACS 的病例较少，且女性的结果不一致。
总之，适量摄入肥鱼与中年男性 ACS 风险降低相关，而女性中则未观察到一致的关联。
