肾移植后蛋白尿和肾功能再次衰竭的不常见原因：移植肾中局部新发性 AL 淀粉样变性。

Unusual cause of proteinuria and re-renal failure after kidney transplantation: de novo localized AL amyloidosis in renal allograft.

机构信息

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, #79 Qingchun Road, 310003 Hangzhou, China.

出版信息

Int Urol Nephrol. 2010 Jun;42(2):507-11. doi: 10.1007/s11255-009-9635-9. Epub 2009 Sep 11.

DOI:10.1007/s11255-009-9635-9

PMID:19757136

Abstract

Amyloidosis results from the deposition of amyloid proteins in organ and tissues. It can be systemic or localized. Localized primary amyloidosis in renal allograft is an extremely rare clinical condition. We describe here a 46-year-old man who developed proteinuria and re-renal failure 5 years after receiving deceased renal allograft and proved to be a case of isolated primary AL amyloidosis in renal allograft confirmed by clinical investigations and renal biopsy.

摘要

淀粉样变性是由淀粉样蛋白在器官和组织中的沉积引起的。它可以是全身性的，也可以是局限性的。肾移植中局限性原发性淀粉样变性是一种极为罕见的临床情况。我们在此描述了一位 46 岁男性，他在接受已故肾移植 5 年后出现蛋白尿和肾功能衰竭，并通过临床研究和肾活检证实为肾移植中孤立性原发性 AL 淀粉样变性。