在水中利用微波辅助加热进行固相肽合成。
Solid-phase peptide synthesis in water using microwave-assisted heating.
作者信息
Galanis Athanassios S, Albericio Fernando, Grøtli Morten
机构信息
Department of Chemistry, Medicinal Chemistry, University of Gothenburg, SE-412 96 Goteborg, Sweden.
出版信息
Org Lett. 2009 Oct 15;11(20):4488-91. doi: 10.1021/ol901893p.
PMID:19757802
Abstract
An approach using water as a solvent (coupling and deprotection) was developed for the solid-phase synthesis of peptides using the most common Boc-amino acid derivatives. Key aspects of this methodology are the use of a PEG-based resin, EDC-HONB as a coupling method, and microwave irradiation as an energy source.
摘要
利用水作为溶剂（偶联和脱保护）的方法被开发用于使用最常见的Boc-氨基酸衍生物进行肽的固相合成。该方法的关键方面包括使用基于聚乙二醇的树脂、以EDC-HONB作为偶联方法以及以微波辐射作为能源。
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