在水中利用微波辅助加热进行固相肽合成。

Solid-phase peptide synthesis in water using microwave-assisted heating.

作者信息

Galanis Athanassios S, Albericio Fernando, Grøtli Morten

机构信息

Department of Chemistry, Medicinal Chemistry, University of Gothenburg, SE-412 96 Goteborg, Sweden.

出版信息

Org Lett. 2009 Oct 15;11(20):4488-91. doi: 10.1021/ol901893p.

DOI:10.1021/ol901893p

PMID:19757802

Abstract

An approach using water as a solvent (coupling and deprotection) was developed for the solid-phase synthesis of peptides using the most common Boc-amino acid derivatives. Key aspects of this methodology are the use of a PEG-based resin, EDC-HONB as a coupling method, and microwave irradiation as an energy source.

摘要

利用水作为溶剂（偶联和脱保护）的方法被开发用于使用最常见的Boc-氨基酸衍生物进行肽的固相合成。该方法的关键方面包括使用基于聚乙二醇的树脂、以EDC-HONB作为偶联方法以及以微波辐射作为能源。