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水性和胶束介质中肽合成的挑战与成就

Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media.

作者信息

Bordignon Francesca, Scarso Alessandro, Angelini Alessandro

机构信息

Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca' Foscari Venezia, via Torino 155, 30172, Mestre Venezia, Italy.

European Centre for Living Technology (ECLT), Ca' Bottacin, Dorsoduro 3911, Calle Crosera, 30123, Venezia, Italy.

出版信息

Chembiochem. 2025 Jun 3;26(11):e202500099. doi: 10.1002/cbic.202500099. Epub 2025 May 21.

DOI:10.1002/cbic.202500099
PMID:40289017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12135130/
Abstract

Peptides are being increasingly explored for drug development as well as other applications, ranging from research tools to food additives. This growing interest in peptides has led to the need to develop new sustainable synthetic approaches for this class of molecules. The present review article focuses on the synthesis of peptides in aqueous media to drastically reduce organic solvent use and its consequent environmental impact. After some pioneering investigations about solid-phase peptide synthesis in water, the field is experiencing a renaissance also for the synthesis in solution spurred by increasing applications enabled by micellar catalysis. In this contribution, the challenges and opportunities offered by using aqueous and micellar media in the chemical synthesis of peptides are critically discussed.

摘要

肽正越来越多地被用于药物开发以及其他应用，范围从研究工具到食品添加剂。对肽的这种日益增长的兴趣导致需要为这类分子开发新的可持续合成方法。本综述文章聚焦于在水性介质中合成肽，以大幅减少有机溶剂的使用及其对环境的影响。在对水中固相肽合成进行了一些开创性研究之后，由于胶束催化带来的应用增加，溶液合成领域也正在复兴。在本论文中，对在肽的化学合成中使用水性和胶束介质所带来的挑战和机遇进行了批判性讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0737/12135130/a19e423588a9/CBIC-26-e202500099-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0737/12135130/6e34bb1d771e/CBIC-26-e202500099-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0737/12135130/a8c9200e4584/CBIC-26-e202500099-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0737/12135130/4183912c3f6d/CBIC-26-e202500099-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0737/12135130/ad40b51f10bf/CBIC-26-e202500099-g027.jpg
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本文引用的文献

1
Aqueous Micelles as Solvent, Ligand, and Reaction Promoter in Catalysis.水相胶束作为催化中的溶剂、配体和反应促进剂
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Epimerisation in Peptide Synthesis.肽合成中的差向异构化。
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Is Micellar Catalysis Green Chemistry?胶束催化是绿色化学吗？
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Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green.由羧酸直接形成酰胺/肽键：无需传统偶联试剂，一锅法，绿色环保。
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Water-Based Solid-Phase Peptide Synthesis without Hydroxy Side Chain Protection.无羟基侧链保护的水相固相多肽合成。
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Therapeutic peptides: current applications and future directions.治疗性肽：当前的应用及未来方向。
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