Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Department of Health Sciences, University "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
Molecules. 2023 Oct 19;28(20):7165. doi: 10.3390/molecules28207165.
Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address. A wide variety of natural and modified peptides have been obtained and studied, and many others are advancing in clinical trials, covering multiple therapeutic areas. As the demand for peptide-based therapies grows, so does the need for sustainable and environmentally friendly synthesis methods. Traditional peptide synthesis, while effective, often involves environmentally draining processes, generating significant waste and consuming vast resources. The integration of green chemistry offers sustainable alternatives, prioritizing eco-friendly processes, waste reduction, and energy conservation. This review delves into the transformative potential of applying green chemistry principles to peptide synthesis by discussing relevant examples of the application of such approaches to the production of active pharmaceutical ingredients (APIs) with a peptide structure and how these efforts are critical for an effective green transition era in the pharmaceutical field.
肽是当代新型高效、选择性和安全治疗药物研究的前沿领域。它们的出现改变了药物研发的格局，为传统小分子药物难以解决的问题提供了新的解决方案。已经获得并研究了各种各样的天然和修饰肽，还有许多其他肽正在临床试验中进行，涵盖了多个治疗领域。随着对基于肽的治疗方法的需求不断增长，对可持续和环保的合成方法的需求也在增加。传统的肽合成虽然有效，但往往涉及到环境消耗性的过程，产生大量的废物并消耗大量的资源。绿色化学的整合提供了可持续的替代方案，优先考虑环保的过程、废物减少和能源节约。本文通过讨论将这些方法应用于具有肽结构的活性药物成分（API）生产的相关实例，深入探讨了将绿色化学原则应用于肽合成的变革潜力，以及这些努力对于制药领域有效绿色转型时代的重要性。
