[The effect of a peptide-containing extract of the right hemispheric cortex on the recovery of conditioned reflex activity and on the level of neuromediators in the brain structures of rats after a unilateral frontal lobectomy].

Experiments were conducted on 97 non-inbred [correction of unbred] male rats to study the effect of a peptide-containing extract of the cortex of the right hemisphere of donor rats, who underwent left lobectomy 9 days before the experiment, on restoration of conditioned reflexes of bilateral avoidance and level of neuromediators in the brain structures of recipient rats with a similar damage to the cerebral cortex. It is shown that the brain extract from the right hemisphere of operated on donors has a much higher effect on the restoration of reflexes. At the same time it was found that in left frontal lobectomy this extract produces a most manifest effect on monoamine metabolism in the structures of the right intact hemisphere. It is suggested that a directed effect may possibly be produced on the development of compensatory-restorative process in the central nervous system by endogenous substances of peptide origin which are isolated from brain structures actively contributing to the restoration of disturbed functions.