Grekhova T V, Kudrin V S, Miroshnichenko I I, Romanova G A
Biull Eksp Biol Med. 1987 Jan;103(1):12-4.
The influence of frontal cortex extirpation on the amount of monoamines in the brain structures was investigated in chronic experiments on rats trained according to the method of motor feeding reflexes with bilateral reinforcement. Monoamine levels were measured by high performance liquid chromatography with electrochemical detection. By the ninth day after the ablation serotonin (5-HT) and dopamine (DA) levels were significantly reduced in the cortex and the striatum, respectively, while noradrenaline ++ (NA), 5-HT, dihydroxyphenylacetic and 5-hydroxyindoleacetic acid levels in raphe nuclei and locus coeruleus were increased. The level of conditioned reflex reproduction was 39% on the light and 33% on the sound stimulus. The involvement of monoamines in the recovery of conditioned reflexes after frontal cortex extirpation is discussed.
在对按照双侧强化运动进食反射方法训练的大鼠进行的慢性实验中，研究了额叶皮质切除对脑结构中单胺含量的影响。采用高效液相色谱电化学检测法测定单胺水平。切除术后第9天，皮质和纹状体中的血清素（5-HT）和多巴胺（DA）水平分别显著降低，而中缝核和蓝斑中的去甲肾上腺素（NA）、5-HT、二羟基苯乙酸和5-羟基吲哚乙酸水平升高。条件反射在光刺激下的再现水平为39%，在声刺激下为33%。讨论了单胺在额叶皮质切除后条件反射恢复中的作用。
