Seganti L, Superti F, Bianchi S, Orsi N, Divizia M, Panà A
Istituto di Microbiologia, Facoltà di Medicina, Università La Sapienza, Roma, Italy.
Acta Virol. 1990 Apr;34(2):155-63.
The relationship between plasma membrane receptor organization and cell susceptibility in vitro was investigated in mammalian, avian, fish, and arthropod cell lines infected with fixed rabies virus. IMR32, HeLa, CER, and EPC cells were widely susceptible to infection with CVS virus, whereas a lower level of specific viral antigens was detectable in A. albopictus cells. In spite of these differences, the amount of infectious virus particles bound to the various cell surfaces was similar. Competition experiments carried out with plasma membranes extracted from ability of these components to bind the virus and to prevent infection. The different cellular permissiveness to rabies infection described here did not correlate with significant differences in number or in chemical structure of the receptor binding sites, but more likely with events following virus adsorption.
在感染固定狂犬病病毒的哺乳动物、禽类、鱼类和节肢动物细胞系中，研究了质膜受体组织与体外细胞易感性之间的关系。IMR32、HeLa、CER和EPC细胞对CVS病毒感染广泛易感，而在白纹伊蚊细胞中可检测到较低水平的特异性病毒抗原。尽管存在这些差异，但结合在各种细胞表面的感染性病毒颗粒数量相似。用从能够结合病毒并预防感染的这些成分中提取的质膜进行竞争实验。此处描述的对狂犬病感染的不同细胞允许性与受体结合位点的数量或化学结构的显著差异无关，而更可能与病毒吸附后的事件有关。
