Bristol Centre of Reproductive Medicine, Southmead Hospital, Bristol, UK.
Arch Gynecol Obstet. 2010 Apr;281(4):727-33. doi: 10.1007/s00404-009-1225-7. Epub 2009 Sep 16.
The study explores the relationship between serum Chlamydia antibody titres (CAT) using the whole-cell inclusion immunofluorescence (WIF) test and severity of tubal damage in infertile women undergoing laparoscopy.
Comparisons between the extent of specific lesions, including their severity found at laparoscopy, and CAT levels were analysed in 408 infertile women with tubal damage. CAT levels were assayed using the WIF test.
There were significant differences in the severity of individual lesions (tubal occlusion, tubal pathology, fimbrial state, extent and type of tubal and ovarian adhesions, type of tubal and ovarian adhesions) for both left and right adnexa in relation to CAT (P < 0.0001). The presence and severity of lesions found in one adnexum significantly correlated with the findings on the contra-lateral side (r > 0.5; P < 0.01). The American Fertility Society grades for tubal occlusion and adhesions in the right adnexum did not correlate with CAT.
CAT levels are quantitatively related to the severity of tubal damage in infertile women. Wide variations in the severity of lesions observed in relation to CAT were suggestive of broad individual differences in response to chlamydial infection.
本研究旨在探讨使用全细胞包涵体免疫荧光（WIF）试验检测血清沙眼衣原体抗体滴度（CAT）与行腹腔镜检查的不孕妇女输卵管损伤严重程度之间的关系。
对 408 例输卵管损伤的不孕妇女的特定病变严重程度（包括腹腔镜下发现的严重程度）与 CAT 水平进行比较。采用 WIF 试验检测 CAT 水平。
左、右附件的个体病变（输卵管阻塞、输卵管病变、输卵管伞端状态、输卵管和卵巢粘连的范围和类型、输卵管和卵巢粘连的类型）严重程度与 CAT 存在显著差异（P < 0.0001）。一侧附件的病变存在及其严重程度与对侧附件的发现具有显著相关性（r > 0.5；P < 0.01）。右侧附件的输卵管阻塞和粘连的美国生育协会分级与 CAT 不相关。
CAT 水平与不孕妇女输卵管损伤的严重程度呈定量相关。CAT 与病变严重程度之间存在广泛的差异，提示个体对衣原体感染的反应存在广泛的差异。
