采用遥测分析技术检测小鼠接种减毒活病毒疫苗后的发热反应。
Telemetric analysis to detect febrile responses in mice following vaccination with a live-attenuated virus vaccine.
作者信息
Martin Shannon S, Bakken Russell R, Lind Cathleen M, Reed Douglas S, Price Jessica L, Koeller Craig A, Parker Michael D, Hart Mary Kate, Fine Donald L
机构信息
DynPort Vaccine Company LLC (DVC), A CSC Company, Frederick, MD 21702, USA.
出版信息
Vaccine. 2009 Nov 16;27(49):6814-23. doi: 10.1016/j.vaccine.2009.09.013. Epub 2009 Sep 15.
Abstract
Non-human primates (NHP) are considered to be the most appropriate model for predicting how humans will respond to many infectious diseases. Due to ethical and monetary concerns associated with the use of NHP, rodent models that are as predictive of responses likely to be seen in human vaccine recipients are warranted. Using implanted telemetry devices, body temperature and activity were monitored in inbred and outbred mouse strains following administration of the live-attenuated vaccine for Venezuelan equine encephalitis virus (VEEV), V3526. Following analysis of individual mouse data, only outbred mouse strains showed changes in diurnal temperature and activity profiles following vaccination. Similar changes were observed following VEEV challenge of vaccinated outbred mice. From these studies, we conclude, outbred mouse strains implanted with telemeters are a sensitive model for predicting responses in humans following vaccination.
摘要
非人灵长类动物（NHP）被认为是预测人类对多种传染病反应的最合适模型。由于与使用NHP相关的伦理和资金问题，需要有能像预测人类疫苗接种者可能出现的反应一样具有预测性的啮齿动物模型。使用植入式遥测设备，在给近交系和远交系小鼠品系接种委内瑞拉马脑炎病毒（VEEV）减毒活疫苗V3526后，对其体温和活动进行监测。在对个体小鼠数据进行分析后，只有远交系小鼠品系在接种疫苗后出现了昼夜体温和活动模式的变化。对接种疫苗的远交系小鼠进行VEEV攻击后也观察到了类似变化。从这些研究中，我们得出结论，植入遥测设备的远交系小鼠品系是预测人类接种疫苗后反应的敏感模型。
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