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Differences in postsurgical recovery of CF1 mice after intraperitoneal implantation of radiotelemetry devices through a midline or flank surgical approach.通过中线或侧腹手术入路腹腔内植入无线电遥测设备后，CF1小鼠术后恢复情况的差异。
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本文引用的文献

1
Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.利用基因敲除小鼠和咖啡因揭示A1和A2A腺苷受体在调节心率、体温和运动方面的生理作用。
Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1141-9. doi: 10.1152/ajpheart.00754.2008. Epub 2009 Feb 13.
2
Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice.血管一氧化氮和超氧阴离子促成小鼠性别特异性的程序性心血管生理。
Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R651-62. doi: 10.1152/ajpregu.90756.2008. Epub 2009 Jan 14.
3
Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.A3腺苷受体基因敲除小鼠在摄入咖啡因、安非他命及处于黑暗环境后行为激活减少。
Physiol Behav. 2008 Dec 15;95(5):668-76. doi: 10.1016/j.physbeh.2008.09.018. Epub 2008 Sep 27.
4
Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice.短期暴露于二手烟会降低小鼠的心率变异性并增加其心律失常易感性。
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H632-9. doi: 10.1152/ajpheart.91535.2007. Epub 2008 Jun 13.
5
Neurovirulence evaluation of Venezuelan equine encephalitis (VEE) vaccine candidate V3526 in nonhuman primates.委内瑞拉马脑炎候选疫苗V3526在非人灵长类动物中的神经毒力评估。
Vaccine. 2008 Jun 25;26(27-28):3497-506. doi: 10.1016/j.vaccine.2008.04.044. Epub 2008 May 7.
6
The effects on heart rate and temperature of mice and vas deferens responses to noradrenaline when their cage mates are subjected to daily restraint stress.当小鼠的笼伴每天遭受束缚应激时，对小鼠心率、体温以及输精管对去甲肾上腺素反应的影响。
Lab Anim. 2008 Apr;42(2):140-8. doi: 10.1258/la.2007.06030e.
7
Protection of hamsters by Venezuelan equine encephalitis virus candidate vaccine V3526 against lethal challenge by mosquito bite and intraperitoneal injection.委内瑞拉马脑炎病毒候选疫苗V3526对仓鼠的保护作用：抵抗蚊虫叮咬和腹腔注射所致的致死性攻击
Am J Trop Med Hyg. 2008 Feb;78(2):328-32.
8
Venezuelan equine encephalitis virus vaccine candidate (V3526) safety, immunogenicity and efficacy in horses.委内瑞拉马脑炎病毒候选疫苗（V3526）在马匹中的安全性、免疫原性和效力
Vaccine. 2007 Feb 26;25(10):1868-76. doi: 10.1016/j.vaccine.2006.10.030. Epub 2006 Oct 27.
9
A plaque neutralization method for arboviruses.一种用于虫媒病毒的蚀斑中和方法。
Proc Soc Exp Biol Med. 1967 Jul;125(3):741-7. doi: 10.3181/00379727-125-32194.
10
Genetically engineered, live, attenuated vaccines protect nonhuman primates against aerosol challenge with a virulent IE strain of Venezuelan equine encephalitis virus.基因工程减毒活疫苗可保护非人灵长类动物免受委内瑞拉马脑炎病毒强毒株气溶胶攻击。
Vaccine. 2005 May 2;23(24):3139-47. doi: 10.1016/j.vaccine.2004.12.023.

采用遥测分析技术检测小鼠接种减毒活病毒疫苗后的发热反应。

Telemetric analysis to detect febrile responses in mice following vaccination with a live-attenuated virus vaccine.

作者信息

Martin Shannon S, Bakken Russell R, Lind Cathleen M, Reed Douglas S, Price Jessica L, Koeller Craig A, Parker Michael D, Hart Mary Kate, Fine Donald L

机构信息

DynPort Vaccine Company LLC (DVC), A CSC Company, Frederick, MD 21702, USA.

出版信息

Vaccine. 2009 Nov 16;27(49):6814-23. doi: 10.1016/j.vaccine.2009.09.013. Epub 2009 Sep 15.

DOI:10.1016/j.vaccine.2009.09.013
PMID:19761841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2783281/
Abstract

Non-human primates (NHP) are considered to be the most appropriate model for predicting how humans will respond to many infectious diseases. Due to ethical and monetary concerns associated with the use of NHP, rodent models that are as predictive of responses likely to be seen in human vaccine recipients are warranted. Using implanted telemetry devices, body temperature and activity were monitored in inbred and outbred mouse strains following administration of the live-attenuated vaccine for Venezuelan equine encephalitis virus (VEEV), V3526. Following analysis of individual mouse data, only outbred mouse strains showed changes in diurnal temperature and activity profiles following vaccination. Similar changes were observed following VEEV challenge of vaccinated outbred mice. From these studies, we conclude, outbred mouse strains implanted with telemeters are a sensitive model for predicting responses in humans following vaccination.

摘要

非人灵长类动物（NHP）被认为是预测人类对多种传染病反应的最合适模型。由于与使用NHP相关的伦理和资金问题，需要有能像预测人类疫苗接种者可能出现的反应一样具有预测性的啮齿动物模型。使用植入式遥测设备，在给近交系和远交系小鼠品系接种委内瑞拉马脑炎病毒（VEEV）减毒活疫苗V3526后，对其体温和活动进行监测。在对个体小鼠数据进行分析后，只有远交系小鼠品系在接种疫苗后出现了昼夜体温和活动模式的变化。对接种疫苗的远交系小鼠进行VEEV攻击后也观察到了类似变化。从这些研究中，我们得出结论，植入遥测设备的远交系小鼠品系是预测人类接种疫苗后反应的敏感模型。