Department of Psychology, University of New England, Armidale NSW 2351, Australia.
Neurobiol Learn Mem. 2010 Jan;93(1):132-6. doi: 10.1016/j.nlm.2009.09.003. Epub 2009 Sep 15.
We developed a single-trial cue-location memory task in which rats experienced an auditory cue while exploring an environment. They then recalled and avoided the sound origination point after the cue was paired with shock in a separate context. Subjects with medial prefrontal cortical (mPFC) lesions made no such avoidance response, but both lesioned and control subjects avoided the cue itself when presented at test. A follow up assessment revealed no spatial learning impairment in either group. These findings suggest that the rodent mPFC is required for incidental learning or recollection of the location at which a discrete cue occurred, but is not required for cue recognition or for allocentric spatial memory.
我们开发了一种单次试验线索位置记忆任务，在此任务中，大鼠在探索环境时会听到一个声音线索。然后，当该线索与另一个环境中的电击配对时，大鼠会回忆并避免该声音的起源点。内侧前额叶皮质（mPFC）损伤的大鼠没有做出这种回避反应，但损伤组和对照组在测试中都回避了该线索。后续评估显示，两组都没有空间学习障碍。这些发现表明，啮齿动物的 mPFC 对于离散线索出现位置的偶然学习或回忆是必需的，但对于线索识别或以自我为中心的空间记忆则不是必需的。
