生长抑素及其类似物在糖尿病发病机制和治疗中的作用。

Role of somatostatin and its analogues in the pathogenesis and treatment of diabetes mellitus.

作者信息

Gerich J E

机构信息

Department of Medicine, University of Pittsburgh School of Medicine, PA.

出版信息

Metabolism. 1990 Sep;39(9 Suppl 2):52-4. doi: 10.1016/0026-0495(90)90211-t.

DOI:10.1016/0026-0495(90)90211-t

PMID:1976221

Abstract

Somatostatin secreted by pancreatic D cells is a potent inhibitor of insulin, glucagon and growth hormone secretion, as well as other cells. The role of abnormal pancreatic D-cell function in diabetes mellitus is unclear. However, development of long-acting selective somatostatin analogs might prove useful in the treatment of diabetes.

摘要

胰腺D细胞分泌的生长抑素是胰岛素、胰高血糖素和生长激素分泌以及其他细胞功能的强效抑制剂。胰腺D细胞功能异常在糖尿病中的作用尚不清楚。然而，长效选择性生长抑素类似物的研发可能被证明对糖尿病治疗有用。