Click R E, Van Kampen C L
University of Wisconsin-River Falls, River Falls 54022, USA.
J Dairy Sci. 2009 Oct;92(10):4846-51. doi: 10.3168/jds.2009-2129.
The naturally occurring inflammatory bowel disease Johne's, caused by Mycobacterium avium ssp. paratuberculosis (MAP), has many clinical manifestations in common with the human inflammatory bowel disease Crohn's disease. In addition, both lack preventive and curative therapies. Because a high percentage of Crohn's patients harbor MAP, it is not surprising that MAP is at the center of controversy as to its contribution. Special concern is being raised as to what role, if any, food animals play in transmission of MAP to humans. Because management practices, presently considered the best way to control the spread of MAP, have not and most likely will not eliminate MAP from food animals, other preventive or curative measures are needed. The results presented herein show that a unique bacterium, Dietzia ssp. C79793-74, used as a probiotic, was therapeutic for adult paratuberculosis animals, and resulted in a cure rate of 37.5%.
由副结核分枝杆菌（MAP）引起的自然发生的炎症性肠病——副结核病，有许多与人类炎症性肠病克罗恩病相同的临床表现。此外，两者都缺乏预防和治疗方法。由于高比例的克罗恩病患者携带MAP，MAP在其作用方面处于争议的中心也就不足为奇了。人们特别关注食用动物在MAP传播给人类过程中所起的作用（如果有作用的话）。由于目前被认为是控制MAP传播的最佳管理方法尚未且很可能无法从食用动物中消除MAP，因此需要其他预防或治疗措施。本文给出的结果表明，一种用作益生菌的独特细菌——Dietzia ssp. C79793 - 74，对成年副结核病动物具有治疗作用，治愈率为37.5%。
