Garre K
Astra-Gruppen A/S, Albertslund, Medicinsk afdeling.
Ugeskr Laeger. 1990 Aug 27;152(35):2475-8.
For decades, atrial fibrillation was treated exclusively with digoxin. The introduction of Ca-antagonists and beta-blockers has, however, produced valuable alternatives as ventricular function can now be controlled both at rest and during exercise whereas, with digoxin, ventricular function could only be controlled at rest. This review deals with the etiology and electrophysiology of atrial fibrillation together with the effects of Ca-antagonists and beta-blockers on conduction and control of the heart rate during exercise. Documentation of the effects of the different drugs, separately and combined, in the treatment of atrial fibrillation during rest and exercise is presented. It is concluded that alteration in the therapeutic strategy appears reasonable in favour of a combination of digoxin and also Ca-antagonists/beta-blocker.
几十年来，心房颤动一直仅用地高辛治疗。然而，钙拮抗剂和β受体阻滞剂的出现带来了有价值的替代药物，因为现在心室功能在静息和运动时都能得到控制，而使用地高辛时，心室功能只能在静息时得到控制。本文综述了心房颤动的病因和电生理学，以及钙拮抗剂和β受体阻滞剂在运动时对心脏传导和心率控制的影响。文中还介绍了不同药物单独及联合使用在静息和运动时治疗心房颤动的效果记录。得出的结论是，治疗策略的改变似乎是合理的，有利于地高辛与钙拮抗剂/β受体阻滞剂联合使用。
