Pulendran Bali
Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA.
Nat Rev Immunol. 2009 Oct;9(10):741-7. doi: 10.1038/nri2629. Epub 2009 Sep 18.
Despite their great success, we understand little about how effective vaccines stimulate protective immune responses. Two recent developments promise to yield such understanding: the appreciation of the crucial role of the innate immune system in sensing microorganisms and tuning immune responses, and advances in systems biology. Here I review how these developments are yielding insights into the mechanism of action of the yellow fever vaccine, one of the most successful vaccines ever developed, and the broader implications for vaccinology.
尽管疫苗取得了巨大成功，但我们对有效疫苗如何刺激保护性免疫反应却知之甚少。最近的两项进展有望带来此类认识：一是认识到固有免疫系统在感知微生物和调节免疫反应方面的关键作用，二是系统生物学的进展。在此，我将回顾这些进展如何让我们深入了解黄热病疫苗的作用机制（黄热病疫苗是有史以来最成功的疫苗之一），以及它们对疫苗学更广泛的影响。
