Srivastava Shriyansh, Dhoundiyal Shivang, Kumar Sachin, Kaur Awaneet, Khatib Mahalaqua Nazli, Gaidhane Shilpa, Zahiruddin Quazi Syed, Mohanty Aroop, Henao-Martinez Andres F, Krsak Martin, Rodriguez-Morales Alfonso J, Montenegro-Idrogo Juan J, Bonilla-Aldana D Katterine, Sah Ranjit
Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University (DPSRU), Sector 3 Pushp Vihar, New Delhi 110017, India.
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India.
Infez Med. 2024 Dec 1;32(4):434-450. doi: 10.53854/liim-3204-3. eCollection 2024.
Yellow fever poses a substantial global health concern as one of the re-emerging diseases with pandemic potential in a scenario of the worldwide distribution of some vectors (such as ); in the context of climatic change, an unclear knowledge about the immune behaviour of the virus, between other determinants. This review details the historical foundations, intricate evolution of geographical spread, and transmission mechanisms of the disease to understand the behaviour of outbreaks over time in a multifactorial context that could be difficult to understand. This article approaches to epidemiological, pathophysiological, immunological, social determinants, and climatic crisis by understanding possible control mechanisms and anticipating potential future epidemics. This article explores the evidence of yellow fever virus (YFV) pathogenesis and its complex interactions with the immune response in the host, the vector, and in the context of immunisation. These discussions contribute to a more comprehensive understanding of the disease's progression. Despite the global presence of the vector and other factors that could facilitate an epidemic spread, yellow fever outbreaks have remained confined to specific endemic areas. This limited distribution is not entirely understood. However, it may be influenced by the complex immune interactions between the virus, the vector, and the host, preventing its spread to other regions.
黄热病作为一种在某些病媒（如……）全球分布的情况下具有大流行潜力的再度出现的疾病之一，对全球健康构成了重大威胁；在气候变化的背景下，人们对该病毒的免疫行为以及其他一些决定因素的了解尚不清楚。本综述详细阐述了该疾病的历史根源、复杂的地理传播演变以及传播机制，以便在一个可能难以理解的多因素背景下了解疫情随时间的发展情况。本文通过了解可能的控制机制并预测未来潜在的疫情，探讨了流行病学、病理生理学、免疫学、社会决定因素和气候危机等方面。本文探讨了黄热病毒（YFV）发病机制的证据及其在宿主、病媒以及免疫接种背景下与免疫反应的复杂相互作用。这些讨论有助于更全面地理解该疾病的发展过程。尽管存在病媒的全球分布以及其他可能促进疫情传播的因素，但黄热病疫情仍局限于特定的流行地区。这种有限的分布情况尚未完全弄清楚。然而，它可能受到病毒、病媒和宿主之间复杂免疫相互作用的影响，从而阻止其传播到其他地区。
