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本文引用的文献

1
Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors.
Carbohydr Res. 2009 Mar 31;344(5):586-91. doi: 10.1016/j.carres.2009.01.001. Epub 2009 Jan 17.
2
Triazole-linked analogue of deoxyribonucleic acid ((TL)DNA): design, synthesis, and double-strand formation with natural DNA.脱氧核糖核酸的三唑连接类似物（（TL）DNA）：设计、合成及其与天然DNA的双链形成
Org Lett. 2008 Sep 4;10(17):3729-32. doi: 10.1021/ol801230k. Epub 2008 Jul 26.
3
Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.III型泛酸激酶底物结合的结构基础及催化机制
Biochemistry. 2008 Feb 5;47(5):1369-80. doi: 10.1021/bi7018578. Epub 2008 Jan 11.
4
Carbohydrate-appended curdlans as a new family of glycoclusters with binding properties both for a polynucleotide and lectins.碳水化合物连接的凝结多糖作为一类新型糖簇，对多核苷酸和凝集素均具有结合特性。
Org Biomol Chem. 2007 Aug 7;5(15):2404-12. doi: 10.1039/b703720a. Epub 2007 Jun 26.
5
Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase.
Bioorg Med Chem Lett. 2007 Aug 15;17(16):4456-9. doi: 10.1016/j.bmcl.2007.06.013. Epub 2007 Jun 8.
6
Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology.炭疽芽孢杆菌III型泛酸激酶在2.0埃分辨率下的结构：对辅酶A依赖性氧化还原生物学的启示
Biochemistry. 2007 Mar 20;46(11):3234-45. doi: 10.1021/bi062299p. Epub 2007 Feb 27.
7
Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties.原核生物II型和III型泛酸激酶：相同的单体折叠形成具有不同催化特性的二聚体。
Structure. 2006 Aug;14(8):1251-61. doi: 10.1016/j.str.2006.06.008.
8
Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria.III型泛酸激酶的晶体结构：深入了解一种在细菌中普遍分布的必需辅酶A生物合成酶的作用机制
J Bacteriol. 2006 Aug;188(15):5532-40. doi: 10.1128/JB.00469-06.
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Sonochemistry: a powerful way of enhancing the efficiency of carbohydrate synthesis.声化学：提高碳水化合物合成效率的有效方法。
J Org Chem. 2006 Jul 7;71(14):5179-85. doi: 10.1021/jo060374w.
10
Characterization of a new pantothenate kinase isoform from Helicobacter pylori.幽门螺杆菌一种新的泛酸激酶同工型的特性分析
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核苷三磷酸模拟：一种糖基三唑基核苷作为炭疽芽孢杆菌泛酸激酶的ATP竞争性抑制剂。

Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase.

作者信息

Rowan Andrew S, Nicely Nathan I, Cochrane Nicola, Wlassoff Wjatschesslaw A, Claiborne Al, Hamilton Chris J

机构信息

School of Chemistry and Chemical Engineering, David Keir Building, Stranmillis Road, Queen's University Belfast, Belfast, BT9 5AG.

出版信息

Org Biomol Chem. 2009 Oct 7;7(19):4029-36. doi: 10.1039/b909729e. Epub 2009 Jul 27.

DOI:10.1039/b909729e
PMID:19763307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6074028/
Abstract

The synthesis of a library of nucleoside triphosphate mimetics is described where the Mg(2+) chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhibitors of Bacillus anthracis pantothenate kinase and a competitive inhibitor has been identified with a K(i) that is 3-fold lower than the K(m) value of ATP.

摘要

描述了核苷三磷酸模拟物文库的合成，其中镁离子螯合的三磷酸侧链被不带电荷的亚甲基-三唑连接的单糖侧链取代。这些化合物已被评估为炭疽芽孢杆菌泛酸激酶的抑制剂，并鉴定出一种竞争性抑制剂，其抑制常数（K(i)）比ATP的米氏常数（K(m)）低3倍。