Foster Robert S, Huang Jianhui, Vivat Jérôme F, Browne Duncan L, Harrity Joseph P A
Department of Chemistry, University of Sheffield, Sheffield, UK S3 7HF.
Org Biomol Chem. 2009 Oct 7;7(19):4052-6. doi: 10.1039/b910632d. Epub 2009 Jul 27.
A concise synthesis of three members of the withasomnine family of natural products is reported. The synthesis features a regioselective sydnone-alkynylboronate cycloaddition followed by Suzuki cross coupling and silyl group removal, and marks the first divergent approach to this family of pyrazole based natural products.
报道了天然产物维沙索宁家族三个成员的简洁合成方法。该合成方法的特点是区域选择性的 sydnone-炔基硼酸酯环加成反应，随后进行铃木交叉偶联反应和硅基去除反应，这标志着首次以不同方法合成这一基于吡唑的天然产物家族。
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