Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Int J Cardiovasc Imaging. 2010 Jan;26(1):5-17. doi: 10.1007/s10554-009-9509-3. Epub 2009 Sep 18.
Three-dimensional quantitative coronary angiography (3D QCA) has been encouraged by the increasing need to better assess vessel dimensions and geometry for interventional purposes. A novel 3D QCA system based on biplane X-ray angiograms is presented in this paper. By correcting for the isocenter offset and by improving the epipolar constraint for corresponding two angiographic projections, accurate and robust reconstruction of the vessel centerline is achieved and the reproducibility of its applications, e.g., the assessments of obstruction length and optimal viewing angle, is guaranteed. The accuracy and variability in assessing the obstruction length and optimal bifurcation viewing angle were investigated by using phantom experiments. The segment length assessed by 3D QCA correlated well with the true wire segment length (r (2) = 0.999) and the accuracy and precision were 0.04 +/- 0.25 mm (P < 0.01). 3D QCA slightly underestimated the rotation angle (difference: -1.5 degrees +/- 3.6 degrees , P < 0.01), while no significant difference was observed for the angulation angle (difference: -0.2 degrees +/- 2.4 degrees , P = 0.54). In conclusion, the new 3D QCA approach allows highly accurate and precise assessments of obstruction length and optimal viewing angle from X-ray angiography.
三维定量冠状动脉造影（3D QCA）因其能够更好地评估介入治疗目的的血管尺寸和形态而受到越来越多的关注。本文提出了一种基于双平面 X 射线血管造影的新型 3D QCA 系统。通过校正等中心偏移，并改进对应两个血管造影投影的对极约束，可以实现血管中心线的精确和稳健重建，并保证其应用的可重复性，例如阻塞长度和最佳观察角度的评估。通过使用体模实验研究了评估阻塞长度和最佳分叉观察角度的准确性和可变性。3D QCA 评估的节段长度与真实导丝节段长度具有很好的相关性（r（2）= 0.999），准确性和精密度为 0.04 +/- 0.25mm（P < 0.01）。3D QCA 略微低估了旋转角度（差异：-1.5 度 +/- 3.6 度，P < 0.01），而对角度（差异：-0.2 度 +/- 2.4 度，P = 0.54）没有明显差异。总之，新的 3D QCA 方法允许从 X 射线血管造影中高度准确和精确地评估阻塞长度和最佳观察角度。
