Altan Mehmet, Atukeren Pinar, Mengi Murat, Metin Gokhan, Cakar Lutfi, Gumustas Koray
Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Turkey.
Chin J Physiol. 2009 Apr 30;52(2):106-12.
Live high train low (LHTL) is a well-known training model for preparation of competitions. In this study, the thiobarbituric acid reacting substances (TBARS) levels and superoxide dismutase (SOD) activity were determined in heart, lung and muscle tissues of rats. They were intermittently exposed to hypobaric pressure of 523 mmHg, corresponding to an altitude of 3,000 m, and they performed swim training at sea level. Two groups of male rats were trained to swim for thirty minutes a day and 4 days a week, lasting 9 weeks. Two groups were exposed to hypobaria for 120 min a day and 4 days a week for 9 weeks in pressure cabin. In heart tissue, TBARS levels of normobaric trained (NbT) group was higher (P < 0.05) than those of the normobaric sedentary (control) group. TBARS levels of hypobaric trained (HbT) group was higher than those of the control and hypobaric sedentary (Hb) groups (P < 0.001; P < 0.01, respectively). TBARS levels of lung tissue of HbT group was also higher than those of the same groups (control; P < 0.01, Hb; P < 0.05, respectively). In muscle tissue, TBARS levels of HbT group was higher than those of the sedentary groups (control; P < 0.001, Hb; P < 0.05, respectively). SOD activity of heart tissue of HbT group was higher (P < 0.001) than that of the other groups. In lung tissue, SOD activity of control group was lower than that of the other groups (HbT; P < 0.001, NbT; P < 0.01, Hb; P < 0.01, respectively). In muscle tissue, SOD activity of HbT group was higher (P < 0.01) than that of the control group. The results of this study suggest that intermittent hypobaric exposure may augment exercise-induced oxidative stress in heart, lung and muscle of trained rats.
高住低训（LHTL）是一种著名的用于比赛准备的训练模式。在本研究中，测定了大鼠心脏、肺和肌肉组织中的硫代巴比妥酸反应物质（TBARS）水平和超氧化物歧化酶（SOD）活性。它们间歇性暴露于相当于海拔3000米的523 mmHg低压环境中，并在海平面进行游泳训练。两组雄性大鼠每天训练游泳30分钟，每周训练4天，持续9周。两组在压力舱中每天暴露于低压环境120分钟，每周暴露4天，持续9周。在心脏组织中，常压低氧训练（NbT）组的TBARS水平高于常压久坐（对照）组（P < 0.05）。低压低氧训练（HbT）组的TBARS水平高于对照组和低压久坐（Hb）组（分别为P < 0.001；P < 0.01）。HbT组肺组织的TBARS水平也高于相同组（对照组；P < 0.01，Hb组；P < 0.05）。在肌肉组织中，HbT组的TBARS水平高于久坐组（对照组；P < 0.001，Hb组；P < 0.05）。HbT组心脏组织的SOD活性高于其他组（P < 0.001）。在肺组织中，对照组的SOD活性低于其他组（HbT组；P < 0.001，NbT组；P < 0.01，Hb组；P < 0.01）。在肌肉组织中，HbT组的SOD活性高于对照组（P < 0.01）。本研究结果表明，间歇性低压暴露可能会增强训练大鼠心脏、肺和肌肉中运动诱导的氧化应激。
