a Laboratory of Atmospheric Pollution, Graduate Program in Health Science , Federal University of Health Sciences of Porto Alegre (UFCSPA) , Porto Alegre , Brazil.
b Research Department , Sul-Rio-Grandense Federal Institute of Education, Science and Technology , Gravataí , Brazil.
Redox Rep. 2018 Dec;23(1):146-152. doi: 10.1080/13510002.2018.1475993.
The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution.
Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SED-CrPic); ROFA exposure and trained (ROFA-AT); ROFA exposure, supplemented and trained (ROFA-AT-CrPic); sedentary (Sal-SED); sedentary and supplemented (Sal-SED-CrPic); trained (Sal-AT); and supplemented and trained (Sal-AT-CrPic). Rats exposed to ROFA (air pollution) received 50 µg of ROFA daily via intranasal instillation. Supplemented rats received CrPic (1 mg/kg/day) daily by oral gavage. Exercise training was performed on a rat treadmill (5×/week). Oxidative parameters were evaluated at the end of protocols.
Trained groups demonstrated lower gain of body mass (P < .001) and increased exercise tolerance (P < .0001). In the gastrocnemius, trained groups demonstrated increased SOD activity (P < .0001) and decrease levels of TBARS (P = .0014), although CAT activity did not differ among groups (P = .4487).
Air pollution exposure did not lead to alterations in oxidative markers in lungs and heart, and exercise training was responsible for decreasing oxidative stress of the gastrocnemius.
本研究旨在探讨吡啶羧酸铬（CrPic）补充剂联合有氧运动对暴露于空气污染的大鼠氧化应激相关指标的影响。
61 只雄性 Wistar 大鼠分为 8 组：残余油飞灰（ROFA）暴露和安静（ROFA-SED）；ROFA 暴露、安静且补充（ROFA-SED-CrPic）；ROFA 暴露、训练和补充（ROFA-AT-CrPic）；ROFA 暴露、补充且训练（ROFA-AT）；安静（Sal-SED）；安静且补充（Sal-SED-CrPic）；训练（Sal-AT）；以及补充且训练（Sal-AT-CrPic）。ROFA 暴露（空气污染）组大鼠通过鼻腔滴注每天接受 50μg 的 ROFA。补充 CrPic 组大鼠每天通过口服灌胃接受 1mg/kg 的 CrPic。每周进行 5 次大鼠跑步机运动训练。在方案结束时评估氧化参数。
训练组大鼠体重增加减少（P < .001），运动耐量增加（P < .0001）。在比目鱼肌中，训练组 SOD 活性增加（P < .0001），TBARS 水平降低（P = .0014），而 CAT 活性在各组间无差异（P = .4487）。
空气污染暴露不会导致肺和心脏氧化标志物的改变，运动训练负责降低比目鱼肌的氧化应激。
