Devoto S H
Laboratory of Neurobiology, Rockefeller University, New York, New York 10021.
Experientia. 1990 Sep 15;46(9):916-22. doi: 10.1007/BF01939384.
The neuronal growth cone is a semi-autonomous portion of the developing neuron that is highly specialized for motile activity. Migrating neurons may share some features with neuronal growth cones. I review some of what has been learned about growth cone initiation, the differentiation of axons and dendrites, the role of the cytoskeleton in motility, the movements of membrane vesicles, the factors regulating the rate and direction of growth cone movement, and the further differentiation of growth cones as they enter the target area and initiate synaptogenesis. Where appropriate, I draw comparisons to what is known about the migration of neurons.
神经元生长锥是发育中神经元的一个半自主部分，高度特化以进行运动活动。迁移的神经元可能与神经元生长锥有一些共同特征。我回顾了一些关于生长锥起始、轴突和树突的分化、细胞骨架在运动中的作用、膜泡的运动、调节生长锥运动速率和方向的因素，以及生长锥进入靶区域并启动突触形成时的进一步分化等方面的研究成果。在适当的地方，我会将其与已知的神经元迁移情况进行比较。
