Decktor D L, Robinson M G
Oklahoma Foundation for Digestive Research, Oklahoma City.
Hepatogastroenterology. 1990 Jul;37 Suppl 1:11-7.
In the usual clinical setting, symptomatic gastroesophageal reflux can be equated with heartburn; however, the diagnosis of gastroesophageal reflux disease (GERD) can be obscure. Recent improvements in the quality of fiberoptic endoscopy along with other imaging and diagnostic techniques have permitted a more complete understanding of the pathophysiology of gastroesophageal reflux. The continued development of antisecretory, prokinetic, and mucosal protective agents allows the gastroenterologist a choice of effective therapeutic approaches to deal with contributing factors such as gastric acid secretion, lower esophageal sphincter pressure, or gastric motility. Although standard doses of potent H2-receptor antagonists are the focus of current reflux disease therapy, increasingly aggressive regimens will probably become available for refractory patients.
在通常的临床环境中，有症状的胃食管反流可等同于烧心；然而，胃食管反流病（GERD）的诊断可能并不明确。近年来，纤维内镜质量的提高以及其他成像和诊断技术的发展，使人们对胃食管反流的病理生理学有了更全面的认识。抗分泌、促动力和黏膜保护剂的不断发展，使胃肠病学家能够选择有效的治疗方法来应对胃酸分泌、食管下括约肌压力或胃动力等促成因素。尽管标准剂量的强效H2受体拮抗剂是目前反流病治疗的重点，但对于难治性患者，可能会有越来越积极的治疗方案。
