Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, IISPV, Universitat Rovira i Virgili, C/Sant Joan s/n, 43201 Reus, Spain.
Phytomedicine. 2010 Mar;17(3-4):186-91. doi: 10.1016/j.phymed.2009.08.006. Epub 2009 Sep 17.
Diet supplementation and/or modulation is an important strategy to significantly improve human health. The search of plants as additional sources of bioactive phenolic compounds is relevant in this context. The aqueous extract of Hibiscus sabdariffa is rich in anthocyanins and other phenolic compounds including hydroxycitric and chlorogenic acids. Using this extract we have shown an effective protection of cultured peripheral blood mononuclear cells from the cellular death induced by H(2)O(2) and a significant role in the production of inflammatory cytokines. In vitro, the extract promotes the production of IL-6 and IL-8 and decreases the concentration of MCP-1 in supernatants in a dose-dependent manner. In humans, the ingestion of an acute dose of the extract (10g) was well tolerated and decreased plasma MCP-1 concentrations significantly without further effects on other cytokines. This effect was not due to a concomitant increase in the antioxidant capacity of plasma. Instead, its mechanisms probably involve a direct inhibition of inflammatory and/or metabolic pathways responsible for MCP-1 production, and may be relevant in inflammatory and chronic conditions in which the role of MCP-1 is well established. If beneficial effects are confirmed in patients, Hibiscus sabdariffa could be considered a valuable traditional herbal medicine for the treatment of chronic inflammatory diseases with the advantage of being devoid of caloric value or potential alcohol toxicity.
饮食补充和/或调节是显著改善人类健康的重要策略。在这方面，寻找植物作为生物活性酚类化合物的额外来源是相关的。洛神花的水提取物富含花色苷和其他酚类化合物，包括羟基柠檬酸和绿原酸。使用这种提取物，我们已经证明它可以有效地保护培养的外周血单核细胞免受 H(2)O(2)诱导的细胞死亡，并在产生炎症细胞因子方面发挥重要作用。在体外，该提取物以剂量依赖的方式促进 IL-6 和 IL-8 的产生，并降低上清液中 MCP-1 的浓度。在人类中，摄入急性剂量的提取物（10g）耐受性良好，可显著降低血浆 MCP-1 浓度，而对其他细胞因子没有进一步影响。这种作用不是由于血浆抗氧化能力的同时增加所致。相反，其机制可能涉及直接抑制负责 MCP-1 产生的炎症和/或代谢途径，并且在炎症和慢性疾病中可能具有相关性，其中 MCP-1 的作用已得到充分确立。如果在患者中证实有益效果，那么洛神花可能被认为是一种有价值的传统草药，可用于治疗慢性炎症性疾病，其优点是不含热量值或潜在的酒精毒性。
