Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
FEBS Lett. 2009 Dec 17;583(24):3984-91. doi: 10.1016/j.febslet.2009.09.030.
Understanding of the cell cycle control logic in Caulobacter has progressed to the point where we now have an integrated view of the operation of an entire bacterial cell cycle system functioning as a state machine. Oscillating levels of a few temporally-controlled master regulator proteins in a cyclical circuit drive cell cycle progression. To a striking degree, the cell cycle regulation is a whole cell phenomenon. Phospho-signaling proteins and proteases dynamically deployed to specific locations on the cell wall are vital. An essential phospho-signaling system integral to the cell cycle circuitry is central to accomplishing asymmetric cell division.
我们现在拥有了一个完整的细菌细胞周期系统作为一个状态机运行的综合视图。在一个周期性的回路中，少数受时间控制的主调控蛋白的波动水平驱动细胞周期的进行。在惊人的程度上，细胞周期的调控是一个整体细胞的现象。动态地部署到细胞壁特定位置的磷酸化信号蛋白和蛋白酶是至关重要的。一个与细胞周期电路密切相关的重要磷酸化信号系统是完成不对称细胞分裂的关键。
