Holtzendorff Julia, Reinhardt Jens, Viollier Patrick H
UMR 7144-CNRS-UPMC, Station Biologique de Roscoff, Plankton, France 29680, Roscoff, France.
Bioessays. 2006 Apr;28(4):355-61. doi: 10.1002/bies.20384.
Significant strides have been made in recent years towards understanding the molecular basis of cell cycle progression in the model bacterium Caulobacter crescentus. At the heart of cell cycle regulation is a multicomponent transcriptional feedback loop, governing the production of successive regulatory waves or pulses of at least three master regulatory proteins. These oscillating master regulators direct the execution of phase-specific events and, importantly, through intrinsic genetic switches not only determine the length of a given phase, but also provide the driving force that catapults the cell into the next stage of the cell cycle. The genetic switches act as fail safe mechanisms that prevent the cell cycle from relapsing and thus govern the ordered production and the periodicity of these regulatory waves. Here, we detail how the master regulators CtrA, GcrA and DnaA coordinate cell cycle progression and polar development in Caulobacter.
近年来，在了解模式细菌新月柄杆菌细胞周期进程的分子基础方面已经取得了重大进展。细胞周期调控的核心是一个多组分转录反馈环，它控制着至少三种主要调控蛋白的连续调控波或脉冲的产生。这些振荡的主要调控因子指导特定阶段事件的执行，重要的是，通过内在的遗传开关不仅决定给定阶段的长度，还提供推动细胞进入细胞周期下一阶段的驱动力。遗传开关起到故障安全机制的作用，防止细胞周期复发，从而控制这些调控波的有序产生和周期性。在这里，我们详细阐述了主要调控因子CtrA、GcrA和DnaA如何协调新月柄杆菌的细胞周期进程和极性发育。
