Zhuo Wen-Lei, Zhu Bo, Xiang Zhao-Lan, Zhuo Xian-Lu, Cai Lei, Chen Zheng-Tang
Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Arch Med Res. 2009 Jul;40(5):406-10. doi: 10.1016/j.arcmed.2009.05.002.
Helicobacter pylori infection has been thought to play a critical role in gastric carcinoma tumorigenesis and progression. Several studies have been devoted to the relationship between H. pylori infection and lung cancer risk and have generated inconclusive results. In this study we aimed to evaluate the potential association of H. pylori infection with lung cancer risk.
We conducted a search in Medline, OVID, EMBASE and CNKI, covering all published papers until October 2008. The relevant published papers were deliberately selected according to the established inclusion criteria for publications. Essential data were then extracted from the included studies and further analyzed by a systematic meta-analysis.
A total of 98 papers were identified. Of these, four case-control studies met the inclusion criteria and thus were finally selected. Lung cancer risk for H. pylori infection was 3.24-fold (95% CI=1.11-9.47) (Z=2.15, p<0.05) compared with the controls.
The pooled data suggest infection of H. pylori as a potential risk factor for lung cancer.
幽门螺杆菌感染被认为在胃癌的发生和发展中起关键作用。已有多项研究致力于探讨幽门螺杆菌感染与肺癌风险之间的关系，但结果尚无定论。在本研究中，我们旨在评估幽门螺杆菌感染与肺癌风险之间的潜在关联。
我们检索了Medline、OVID、EMBASE和中国知网，涵盖截至2008年10月发表的所有论文。根据既定的纳入标准，特意挑选了相关的已发表论文。然后从纳入研究中提取基本数据，并通过系统的荟萃分析进行进一步分析。
共识别出98篇论文。其中，四项病例对照研究符合纳入标准，最终被选中。与对照组相比，幽门螺杆菌感染导致的肺癌风险为3.24倍（95%置信区间=1.11-9.47）（Z=2.15，p<0.05）。
汇总数据表明，幽门螺杆菌感染可能是肺癌的一个风险因素。
