Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Düsseldorf, Düsseldorf, Germany.
Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Düsseldorf, Düsseldorf, Germany
BMJ Open Gastroenterol. 2024 Aug 24;11(1):e001377. doi: 10.1136/bmjgast-2024-001377.
() is a gram-negative gastrointestinal pathogen that colonises the human stomach and is considered a major risk factor for gastric cancer and mucosa-associated lymphoid tissue lymphoma. Furthermore, is a potential trigger of a wide spectrum of extragastric cancer entities, extraintestinal chronic inflammatory processes and autoimmune diseases. In the present study, we evaluated the association between infection and its eradication with the development of subsequent gastrointestinal and non-gastrointestinal cancer.
We identified 25 317 individuals with and 25 317 matched individuals without a diagnosis of from the Disease Analyzer database (IQVIA). A subsequent cancer diagnosis was analysed using Kaplan-Meier and conditional Cox-regression analysis as a function of and its eradication.
After 10 years of follow-up, 12.8% of the cohort and 11.8% of the non- cohort were diagnosed with cancer (p=0.002). Results were confirmed in regression analysis (HR: 1.11; 95% CI 1.04 to 1.18). Moreover, a non-eradicated status (HR: 1.18; 95% CI 1.07 to 1.30) but not an eradicated status (HR: 1.06; 95% CI 0.97 to 1.15) was associated with a subsequent diagnosis of cancer. In subgroup analyses, eradication was negatively associated with bronchus and lung cancer (HR: 0.60; 95% CI 0.44 to 0.83).
Our data from a large outpatient cohort in Germany reveal a distinct association between infection and the subsequent development of cancer. These data might help to identify patients at risk and support eradication strategies in the future.
幽门螺杆菌是一种革兰氏阴性胃肠道病原体，定植于人类胃部，被认为是胃癌和黏膜相关淋巴组织淋巴瘤的主要危险因素。此外，幽门螺杆菌也是广泛的胃癌实体、肠道外慢性炎症过程和自身免疫性疾病的潜在触发因素。在本研究中，我们评估了幽门螺杆菌感染及其根除与随后发生的胃肠道和非胃肠道癌症之间的关联。
我们从 IQVIA 的疾病分析数据库中确定了 25317 例有和 25317 例无幽门螺杆菌诊断的个体。随后使用 Kaplan-Meier 和条件 Cox 回归分析作为幽门螺杆菌及其根除的函数来分析癌症的诊断。
在 10 年的随访后，队列中有 12.8%的人被诊断患有癌症，而非队列中有 11.8%的人被诊断患有癌症（p=0.002）。回归分析结果得到了证实（HR：1.11；95%CI 1.04 至 1.18）。此外，未根除的幽门螺杆菌状态（HR：1.18；95%CI 1.07 至 1.30）而不是已根除的幽门螺杆菌状态（HR：1.06；95%CI 0.97 至 1.15）与随后的癌症诊断相关。在亚组分析中，幽门螺杆菌的根除与支气管和肺癌呈负相关（HR：0.60；95%CI 0.44 至 0.83）。
我们来自德国大型门诊队列的数据揭示了幽门螺杆菌感染与随后癌症发展之间的明显关联。这些数据可能有助于识别高危患者，并支持未来的根除策略。
