Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province 215004, PR China.
Med Hypotheses. 2009 Dec;73(6):1038-40. doi: 10.1016/j.mehy.2009.05.021. Epub 2009 Sep 19.
As a potential biological product, platelet-rich plasma (PRP) has been widely utilized in the areas of oral and maxillofacial reconstruction, bone and soft tissue restoration and wound healing. A recent study reported that the application of PRP on interrupted sciatic nerve could promote remyelinization of peripheral nerve. This renovated a notion that the application of PRP might extend to the nervous system. Most central nervous system (CNS) diseases have a series of common pathological changes in the later period of diseases which induce neurons and glia apoptosis and aggravate neurological dysfunction. It has been demonstrated that the potent restorative function of PRP is mainly based on neurotrophic capacity of preparation rich in growth factors (PRGFs) and scaffolding effect of platelet-rich gel (PRG), all of which could be certified to ameliorate the pathological process of CNS diseases. In view of this, we propose a hypothesis that the application of PRP and its derivatives might provide a novel therapeutic approach for CNS diseases, especially for traumatic brain or spinal cord injury, autoimmune diseases and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.
作为一种潜在的生物制剂，富血小板血浆（PRP）已广泛应用于口腔颌面重建、骨和软组织修复以及伤口愈合等领域。最近的一项研究报告称，PRP 在坐骨神经中断处的应用可以促进周围神经的髓鞘再生。这一发现更新了一种观念，即 PRP 的应用可能扩展到神经系统。大多数中枢神经系统（CNS）疾病在疾病后期都有一系列共同的病理变化，这些变化会导致神经元和神经胶质细胞凋亡，并加重神经功能障碍。已经证明，PRP 的强大修复功能主要基于富含生长因子的制备物的神经营养能力（PRGFs）和血小板丰富凝胶（PRG）的支架作用，所有这些都可以证明能够改善 CNS 疾病的病理过程。有鉴于此，我们提出了一个假设，即 PRP 及其衍生物的应用可能为 CNS 疾病提供一种新的治疗方法，特别是对于创伤性脑或脊髓损伤、自身免疫性疾病以及神经退行性疾病，如阿尔茨海默病、帕金森病和肌萎缩侧索硬化症。
