Division of Hematology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
Int J Neurosci. 2011 Apr;121(4):176-80. doi: 10.3109/00207454.2010.544432. Epub 2011 Jan 19.
Nerve regeneration includes regrowth of injured axons as well as myelination, restoration of synaptic connections and recovery of physiological functions. Platelet-rich plasma (PRP) is prepared from the patient's own blood and contains growth factors that influence wound healing and used in various surgical fields including oral and maxillofacial surgery. When platelets are activated either ex vivo or in vivo, growth factors and proteins were released from platelets' alpha granules. Recent studies proved that PRP could promote regeneration of injured peripheral nerve. This review focuses on current trials using PRP to promote nerve regeneration and repairment, and proposes potential clinical application of PRP for nerve injury in the future.
神经再生包括损伤轴突的再生长以及髓鞘形成、突触连接的恢复和生理功能的恢复。富血小板血浆 (PRP) 是从患者自身血液中制备的，其中含有影响伤口愈合的生长因子，并应用于包括口腔颌面外科在内的各种外科领域。当血小板在体外或体内被激活时，生长因子和蛋白质从血小板的α颗粒中释放出来。最近的研究证明，PRP 可以促进损伤周围神经的再生。本文综述了目前使用 PRP 促进神经再生和修复的临床试验，并对 PRP 在未来神经损伤中的潜在临床应用提出了建议。
