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人类造血与免疫生物学小鼠模型的复兴。

Renaissance for mouse models of human hematopoiesis and immunobiology.

作者信息

Manz Markus G, Di Santo James P

机构信息

Division of Hematology, University Hospital Zurich, Zurich, Switzerland.

出版信息

Nat Immunol. 2009 Oct;10(10):1039-42. doi: 10.1038/ni1009-1039.

DOI:10.1038/ni1009-1039
PMID:19767720
Abstract

More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field.

摘要

在人类白细胞和造血器官首次成功移植到小鼠体内20多年后,科学家们齐聚第二届人源化小鼠国际研讨会,讨论该领域的进展并强调未来期望。

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本文引用的文献

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J Exp Med. 2009 Jun 8;206(6):1423-34. doi: 10.1084/jem.20081720. Epub 2009 Jun 1.
2
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.在人类免疫缺陷病毒感染的人源化BLT小鼠中诱导强大的细胞和体液病毒特异性适应性免疫反应。
J Virol. 2009 Jul;83(14):7305-21. doi: 10.1128/JVI.02207-08. Epub 2009 May 6.
3
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.
人类生长抑素SST受体转基因小鼠:构建及脑表达模式特征分析
Int J Mol Sci. 2021 Apr 4;22(7):3758. doi: 10.3390/ijms22073758.
4
Humanized Rodent Models for Cancer Research.用于癌症研究的人源化啮齿动物模型
Front Oncol. 2020 Sep 11;10:1696. doi: 10.3389/fonc.2020.01696. eCollection 2020.
5
Patient-derived xenograft (PDX) models: characteristics and points to consider for the process of establishment.患者来源的异种移植(PDX)模型:特征及建立过程中需考虑的要点。
J Toxicol Pathol. 2020 Jul;33(3):153-160. doi: 10.1293/tox.2020-0007. Epub 2020 Mar 20.
6
Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.利用下一代人源化小鼠理解正常和恶性人类造血。
Trends Immunol. 2020 Aug;41(8):706-720. doi: 10.1016/j.it.2020.06.004. Epub 2020 Jul 3.
7
Generation of an immunodeficient mouse model of tcirg1-deficient autosomal recessive osteopetrosis.生成tcirg1缺陷型常染色体隐性骨硬化症的免疫缺陷小鼠模型。
Bone Rep. 2020 Jan 7;12:100242. doi: 10.1016/j.bonr.2020.100242. eCollection 2020 Jun.
8
An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses.用于评估肺癌免疫反应的改良患者来源异种移植人源化小鼠模型。
Cancer Immunol Res. 2019 Aug;7(8):1267-1279. doi: 10.1158/2326-6066.CIR-18-0874. Epub 2019 Jun 11.
9
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Immunology. 2019 Jun;157(2):163-172. doi: 10.1111/imm.13061. Epub 2019 May 6.
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Exp Hematol. 2018 Nov;67:18-31. doi: 10.1016/j.exphem.2018.08.004. Epub 2018 Aug 17.
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10
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