Khristov S, Karadzhov I
Vet Med Nauki. 1977;14(1):54-61.
A total of twelve batches of an inactivated vaccine against IBR--IPV, obtained by the authors, were tested in the practice. Vaccinated were 212 calves and 1172 cows and heifers on five dairy farms in different communities. On the basis of virologic, serologic, clinical and epizootiologic investigations the conclusions were drawn that the vaccine is harmless and highly immunogenic. In subcutaneous application at the rate of 3 cm3, twice, it renders protection against IBR--IPV infection (respiratory diseases and abortions) to calves aged more than 30 days for at least 6 months and 8 months for pregnant cows and heifers. On farms with a record of active IBP--IPV infection it is suggested to treat both the diseased and apparently (clinically) normal calves, either therapeutically or prophylactically, with a hyperimmune serum, and after the disease has receded--to resort to vaccination. In comparison with the live vaccines the tested one has been shown to provoke no postvaccinal accidents, eliminating the possibility of maintaining and widening the active infection foci, at otherwise almost comparable immunogenic properties as regards the titers of the virus-neutralizing antibodies produced after the vaccination.
作者获得的总共12批牛传染性鼻气管炎-传染性脓疱性外阴阴道炎灭活疫苗在实际中进行了测试。在不同社区的5个奶牛场，对212头犊牛以及1172头母牛和小母牛进行了接种。基于病毒学、血清学、临床和流行病学调查得出的结论是，该疫苗无害且具有高度免疫原性。以3立方厘米的剂量皮下接种两次，它能为30日龄以上的犊牛提供至少6个月的抗牛传染性鼻气管炎-传染性脓疱性外阴阴道炎感染（呼吸道疾病和流产）保护，为怀孕母牛和小母牛提供8个月的保护。在有牛传染性鼻气管炎-传染性脓疱性外阴阴道炎活跃感染记录的农场，建议对患病和明显（临床上）正常的犊牛，用超免疫血清进行治疗性或预防性处理，在疾病消退后进行疫苗接种。与活疫苗相比，所测试的这种疫苗未引发疫苗接种后事故，消除了维持和扩大活跃感染病灶的可能性，同时在疫苗接种后产生的病毒中和抗体效价方面，免疫原性几乎相当。
