Tsvetkov P, Nikolov A, Boiadzhiev S, Kharalambiev Kh, Gergov P
Vet Med Nauki. 1977;14(8):8-13.
The live attenuated vaccine against infectious rhinotracheitis (LAV), the live trivaccine against infectious rhinotracheitis (LT), the concentrated etanolsaponin vaccine against infectious rhinotracheitis (CESV) and the ethanol-saponin vaccine against infectious rhinotracheitis (ESV) can all be used as immunoprophylactic means in the control of infectious rhinotracheitis in cattle. The first two live vaccines are applied to calves in infection foci, and the two inactivated vaccines are used with cows. The comparative testing of CESV and ESV in experimental conditions on calves has shown that the first possesses higher immunogenicity--used in a twice lower dose it produces several times higher level of the neutralizing antibodies against the infectious rhinotracheitis virus. The use of LAV and LT in the practice under the conditions of established infections of infectious rhinotracheitis in calves has given good results. The immunization of calves at the immediate menace of this infection has lowered the morbidity rate, and death cases were no longer observed. The use of CESV and ESV with pregnant cows on a prophylactic basis against infectious rhinotracheitis has also given good results manifested in the full suppression of abortions.
抗传染性鼻气管炎活疫苗(LAV)、抗传染性鼻气管炎三联活疫苗(LT)、抗传染性鼻气管炎浓缩乙醇皂苷疫苗(CESV)和抗传染性鼻气管炎乙醇皂苷疫苗(ESV)均可作为免疫预防手段用于控制牛的传染性鼻气管炎。前两种活疫苗用于感染病灶的犊牛,两种灭活疫苗用于母牛。在犊牛实验条件下对CESV和ESV进行的对比试验表明,前者具有更高的免疫原性——以低两倍的剂量使用时,它产生的抗传染性鼻气管炎病毒中和抗体水平高出数倍。在犊牛已感染传染性鼻气管炎的情况下,在实际应用中使用LAV和LT取得了良好效果。在这种感染即将发生时对犊牛进行免疫接种降低了发病率,且不再观察到死亡病例。在预防基础上对怀孕母牛使用CESV和ESV预防传染性鼻气管炎也取得了良好效果,表现为完全抑制了流产。