Golovanova O V, Konenkov V I, Shevchenko A V, Smol'nikova M V
Genetika. 2009 Aug;45(8):1118-24.
Based on population analysis of the DRB1, DQA1, DQB1 and TNFA allele frequency distribution patterns, regional features of immunogenetic structure of the population of West Siberia were investigated. Statistically significant linkage disequilibrium within the HLA class II region, as well as between the TNFA and DRB1, DQA1, and DQB1 was demonstrated. Population frequency distribution patterns of two- and multilocus haplotypes were examined.
基于对DRB1、DQA1、DQB1和TNFA等位基因频率分布模式的群体分析，对西西伯利亚人群免疫遗传结构的区域特征进行了研究。结果表明，HLA II类区域内以及TNFA与DRB1、DQA1和DQB1之间存在统计学上显著的连锁不平衡。对两位点和多位点单倍型的群体频率分布模式进行了检查。
