Tomassini Valentina, Palace Jacqueline
Oxford Centre for Functional MRI of the Brain (FMRIB), The University of Oxford, Department of Clinical Neurology, John Radcliffe Hospital, Headley Way, Headigton, Oxford OX39DU, UK.
Expert Rev Neurother. 2009 Sep;9(9):1341-59. doi: 10.1586/ern.09.83.
The hallmark of multiple sclerosis (MS) pathology is the presence of inflammatory demyelinated lesions distributed throughout the CNS. Along with more diffuse tissue abnormalities, it is considered one of the major determinants of neurological deficit in MS. Conventional MRI has contributed to improve our understanding of MS pathology and has provided objective and reliable measures to monitor the effect of treatments. Advanced MRI techniques have offered the opportunity to quantify pathological changes in lesions, as well as in normal-appearing brain tissue and to characterize their dynamics. This review will discuss the characteristics and development of MS lesions and the contribution of conventional and quantitative MRI techniques to understanding pathological changes associated with them.
多发性硬化症（MS）病理学的标志是中枢神经系统（CNS）中存在炎性脱髓鞘病变。连同更弥漫的组织异常一起，它被认为是MS神经功能缺损的主要决定因素之一。传统MRI有助于增进我们对MS病理学的理解，并提供了客观可靠的措施来监测治疗效果。先进的MRI技术提供了量化病变以及正常外观脑组织中病理变化并描述其动态变化的机会。本综述将讨论MS病变的特征和发展，以及传统和定量MRI技术对理解与之相关的病理变化的贡献。
