Department of Bioengineering, UCSD, La Jolla, CA 92093-0412, USA.
FEBS Lett. 2009 Dec 17;583(24):3900-4. doi: 10.1016/j.febslet.2009.09.031.
The first full genome sequences were established in the mid-1990s. Shortly thereafter, genome-scale metabolic network reconstructions appeared. Since that time, we have witnessed an exponential growth in their number and uses. Here I discuss, from a personal point of view, four topics: (1) the placement of metabolic systems biology in the context of broader scientific developments, (2) its foundational concepts, (3) some of its current uses, and (4) some of the expected future developments in the field.
第一个完整的基因组序列是在 20 世纪 90 年代中期建立的。此后不久，出现了基因组规模的代谢网络重建。从那时起，它们的数量和用途呈指数级增长。在这里，我从个人的角度讨论了四个主题：（1）代谢系统生物学在更广泛的科学发展背景下的位置，（2）其基础概念，（3）一些当前的用途，以及（4）该领域未来的一些预期发展。
