Department of General Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Microsurgery. 2010 May;30(4):332-7. doi: 10.1002/micr.20697.
Hepatic stellate cells (HSCs) have demonstrated a strong T-cell inhibitory activity. In a mouse islet transplantation model, cotransplanted HSCs can protect islet allografts from rejection. The involved mechanism is not fully understood. We showed in this study that expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an important apoptosis-inducing ligand, on HSCs was crucial in protection of islet allografts, since HSCs derived from TRAIL knockout mice demonstrated less inhibitory activity towards T-cell proliferative responses, and substantially lost their capacity in protecting cotransplanted islet allografts from rejection, suggesting that TRAIL-mediated T cell apoptotic death is important in HSC-delivered immune regulation activity.
肝星状细胞 (HSCs) 表现出很强的 T 细胞抑制活性。在小鼠胰岛移植模型中，共移植 HSCs 可保护胰岛同种异体移植物免受排斥。其涉及的机制尚不完全清楚。在本研究中我们表明，HSCs 上表达肿瘤坏死因子相关凋亡诱导配体 (TRAIL)，作为一种重要的凋亡诱导配体，对于保护胰岛同种异体移植物至关重要，因为源自 TRAIL 敲除小鼠的 HSCs 对 T 细胞增殖反应的抑制活性较弱，并且显著丧失了保护共移植胰岛同种异体移植物免受排斥的能力，提示 TRAIL 介导的 T 细胞凋亡死亡在 HSC 介导的免疫调节活性中很重要。
