Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China.
Cell Mol Immunol. 2013 Jul;10(4):292-302. doi: 10.1038/cmi.2013.7. Epub 2013 Apr 22.
Because of its unique blood supply, the liver maintains a special local immune tolerogenic microenvironment. Moreover, the liver can impart this immune tolerogenic effect on other organs, thus inducing systemic immune tolerance. The network of hepatic regulatory cells is an important mechanism underlying liver tolerance. Many types of liver-resident antigen-presenting cells (APCs) have immune regulatory function, and more importantly, they can also induce the differentiation of circulating immune cells into regulatory cells to further extend systemic tolerance. Thus, the liver can be seen as a type of 'school', where liver APCs function as 'teachers' and circulating immune cells function as 'students.'
由于其独特的血液供应，肝脏维持着一种特殊的局部免疫耐受微环境。此外，肝脏可以将这种免疫耐受效应赋予其他器官，从而诱导全身免疫耐受。肝调节细胞网络是肝脏耐受的重要机制。许多类型的肝固有抗原呈递细胞（APC）具有免疫调节功能，更重要的是，它们还可以诱导循环免疫细胞分化为调节细胞，从而进一步扩展全身耐受。因此，肝脏可以被视为一种“学校”，其中肝 APC 作为“教师”，循环免疫细胞作为“学生”。
