Essali M A, Das I, de Belleroche J, Hirsch S R
Charing Cross and Westminster Medical School, London, England.
Biol Psychiatry. 1990 Sep 15;28(6):475-87. doi: 10.1016/0006-3223(90)90481-g.
Signal transduction, mediated by the thrombin-stimulated polyphoshoinositide (PPI) turnover was studied in platelets from 44 schizophrenic patients and 33 healthy volunteers. The stimulated generation of inositol phosphates in the schizophrenic group was significantly greater than that in the control group. There was a lack of correlation between this augmented response and a variety of clinical parameters. The response in 9 drug-naive schizophrenic patients was not significantly different from that in controls. The response was significantly augmented in patients receiving neuroleptic treatment and in patients who had been off neuroleptics for at least 4 months. These results indicate that neuroleptic treatment may produce a long-term modification of signal transduction via the PPI system. Further studies are required to elucidate the exact nature of this modification and to explore the possibility that this effect of the neuroleptics may provide a novel approach to understanding the neurochemistry of schizophrenia and to monitoring the neuroleptic treatment.
对44例精神分裂症患者和33名健康志愿者血小板中由凝血酶刺激的多磷酸肌醇（PPI）代谢介导的信号转导进行了研究。精神分裂症组中肌醇磷酸的刺激生成明显高于对照组。这种增强反应与多种临床参数之间缺乏相关性。9例未接受过药物治疗的精神分裂症患者的反应与对照组无显著差异。接受抗精神病药物治疗的患者以及停用抗精神病药物至少4个月的患者的反应明显增强。这些结果表明，抗精神病药物治疗可能通过PPI系统对信号转导产生长期改变。需要进一步研究以阐明这种改变的确切性质，并探索抗精神病药物的这种作用可能为理解精神分裂症的神经化学和监测抗精神病药物治疗提供新方法的可能性。
