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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Drnková J, Nováková O, Kubista V

Department of Animal Physiology and Developmental Biology Faculty of Natural Sciences, Charles University, Prague, Czechoslovakia.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;95(2):125-31. doi: 10.1016/0742-8413(90)90093-o.

Male mice were injected 5 mg/kg isoprenaline (IPRO) daily and the heart weight, dry weight and phospholipid content in the left ventricle determined 24 hr after the last injection on days 1, 3, 5 and 10. 2. The phospholipid content sinks during the experiment, but the onset of the change is different in different phospholipids: for diphosphatidylglycerol it is clearly significant after 3 days, for phosphatidylcholine and phosphatidylethanolamine after 5 days and for sphingomyelin after 10 days; the relative amplitude of the change in this latter phospholipid was greatest of all. 3. If IPRO is given for 3 days and physiological saline for next 7 days, the content of some phospholipids (PE, SM and PG) continued to decrease. This suggests an important delayed effect of IPRO action.

每天给雄性小鼠腹腔注射5毫克/千克异丙肾上腺素（IPRO），并在第1、3、5和10天最后一次注射后24小时测定心脏重量、左心室干重和磷脂含量。2. 实验过程中磷脂含量下降，但不同磷脂变化的起始时间不同：二磷脂酰甘油在3天后变化明显，磷脂酰胆碱和磷脂酰乙醇胺在5天后变化明显，鞘磷脂在10天后变化明显；后一种磷脂变化的相对幅度在所有磷脂中最大。3. 如果给予IPRO 3天，接下来7天给予生理盐水，一些磷脂（PE、SM和PG）的含量继续下降。这表明IPRO作用有重要的延迟效应。

Drnková J, Nováková O, Kubista V

Department of Animal Physiology and Developmental Biology Faculty of Natural Sciences, Charles University, Prague, Czechoslovakia.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;95(2):125-31. doi: 10.1016/0742-8413(90)90093-o.

Male mice were injected 5 mg/kg isoprenaline (IPRO) daily and the heart weight, dry weight and phospholipid content in the left ventricle determined 24 hr after the last injection on days 1, 3, 5 and 10. 2. The phospholipid content sinks during the experiment, but the onset of the change is different in different phospholipids: for diphosphatidylglycerol it is clearly significant after 3 days, for phosphatidylcholine and phosphatidylethanolamine after 5 days and for sphingomyelin after 10 days; the relative amplitude of the change in this latter phospholipid was greatest of all. 3. If IPRO is given for 3 days and physiological saline for next 7 days, the content of some phospholipids (PE, SM and PG) continued to decrease. This suggests an important delayed effect of IPRO action.

每天给雄性小鼠腹腔注射5毫克/千克异丙肾上腺素（IPRO），并在第1、3、5和10天最后一次注射后24小时测定心脏重量、左心室干重和磷脂含量。2. 实验过程中磷脂含量下降，但不同磷脂变化的起始时间不同：二磷脂酰甘油在3天后变化明显，磷脂酰胆碱和磷脂酰乙醇胺在5天后变化明显，鞘磷脂在10天后变化明显；后一种磷脂变化的相对幅度在所有磷脂中最大。3. 如果给予IPRO 3天，接下来7天给予生理盐水，一些磷脂（PE、SM和PG）的含量继续下降。这表明IPRO作用有重要的延迟效应。