α-山竹素对白色念珠菌的抗真菌活性。

Antifungal activity of alpha-mangostin against Candida albicans.

作者信息

Kaomongkolgit Ruchadaporn, Jamdee Kusuma, Chaisomboon Niratcha

机构信息

Oral Diagnosis Department, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand.

出版信息

J Oral Sci. 2009 Sep;51(3):401-6. doi: 10.2334/josnusd.51.401.

DOI:10.2334/josnusd.51.401

PMID:19776506

Abstract

This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alpha-mangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 microg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alpha-mangostin was determined and it was found that alpha-mangostin at 4,000 microg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis.

摘要

本研究旨在检测α-山竹黄酮对白色念珠菌的活性，白色念珠菌是口腔念珠菌病中最重要的致病微生物。将其活性与克霉唑和制霉菌素进行比较。结果表明，α-山竹黄酮对白色念珠菌有效，最低抑菌浓度（MIC）和最低杀菌浓度（MFC）分别为1000和2000微克/毫升。α-山竹黄酮对白色念珠菌的杀伤活性比克霉唑和制霉菌素更有效。测定了α-山竹黄酮的细胞毒性，发现4000微克/毫升的α-山竹黄酮在480分钟内对人牙龈成纤维细胞无毒。α-山竹黄酮强大的抗真菌活性和低毒性使其成为治疗口腔念珠菌病的有前景的药物。